Search on: HISTAMINE H1 ANTAGONISTS 
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Descriptor English:   Histamine H1 Antagonists 
Descriptor Spanish:   Antagonistas de los Receptores Histamínicos H1 
Descriptor Portuguese:   Antagonistas dos Receptores Histamínicos H1 
Synonyms English:   Antagonists, Histamine H1
Antagonists, Histamine H1 Receptor
Antihistamines, Sedating
Blockaders, Histamine H1 Receptor
First Generation H1 Antagonists
H1 Receptor Blockaders
Histamine H1 Blockers
Receptor Blockaders, H1
Classical Antihistamines
Classical Antihistaminics
H1 Antagonists, Histamine
H1 Antihistaminics
Sedating Antihistamines
Antihistaminics, Classical
Antihistaminics, H1
Histamine H1 Receptor Antagonists
Histamine H1 Receptor Blockaders
Antihistamines, Classical  
Tree Number:   D27.505.519.625.375.425.400
D27.505.696.577.375.425.400
Definition English:   Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. 
Indexing Annotation English:   HISTAMINE H1 ANTAGONISTS, NON-SEDATING is also available; DF: HISTAMINE H1 ANTAG
See Related English:   Anti-Allergic Agents
Bronchodilator Agents
Hypersensitivity, Immediate
 
History Note English:   95; was HISTAMINE H1 RECEPTOR BLOCKADERS 1977-94; was ANTIHISTAMINICS 1963-76; ANTIHISTAMINICS, CLASSICAL was ANTIHISTAMINICS see HISTAMINE H1 RECEPTOR BLOCKADERS 1977-90 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications EC economics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   6793 
Unique Identifier:   D006634 

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